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Régulation du glycérol-3-phosphate et du facteur

Régulation du glycérol-3-phosphate et du facteur de croissance des fibroblastes 23 

Objective of the evaluate: Each classical and nonclassical components regulate fibroblast development issue 23 (FGF23), with impacts on gene expression and proteolytic cleavage. Right here, we evaluate current publications that stretch present information on these components.

Current findings: Rising nonclassical FGF23 regulators akin to erythropoietin trigger a balanced improve in FGF23 expression and cleavage, with minimal or no improve in biologically lively intact FGF23 (iFGF23) in blood. Nonetheless, circulating FGF23 profiles could not replicate the bone marrow microenvironment. For instance, granulocyte colony-stimulating issue will increase native marrow iFGF23 ranges with out impacting circulating iFGF23 ranges. The view that phosphate doesn’t improve bone FGF23 manufacturing additionally warrants reconsideration, as phosphate can scale back iFGF23 cleavage and phosphate-containing calciprotein particles improve FGF23 expression. Lastly, a display of renal venous plasma identifies glycerol-3-phosphate as a kidney-derived molecule that circulates to bone and bone marrow, the place it’s transformed to lysophosphatidic acid and indicators via a G-protein coupled receptor to extend FGF23 synthesis.

Abstract: FGF23 regulation is complicated, requiring consideration of recognized and rising stimuli, expression and cleavage, and circulating and native ranges. Current work identifies glycerol-3-phosphate as an FGF23 regulator derived from the injured kidney; whether or not it participates in FGF23 manufacturing downstream of classical or nonclassical components requires additional research.

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Fibroblasts/Epithelial Cells Antibody

abx413036-200l 200 µl
EUR 200

Fibroblasts/Epithelial Cells Antibody (PE)

abx413038-200l 200 µl
EUR 250

Mouse Anti Human Fibroblasts/Epithelial Cells Monoclonal Antibody,RPE

DMABT-49595MH 25 TEST
EUR 514.8

OASA02809-25UG - FIBROBLASTS/EPITHELIAL CELLS Antibody

OASA02809-25UG 25ug
EUR 149

OASA02808-200UG - FIBROBLASTS/EPITHELIAL CELLS Antibody

OASA02808-200UG 0.2mg
EUR 499

OASA02810-100T - Fibroblasts/Epithelial Cells Antibody - PE Conjugated

OASA02810-100T 100Tests
EUR 519

OASA02811-25T - Fibroblasts/Epithelial Cells Antibody - PE Conjugated

OASA02811-25T 25Tests
EUR 219

Fibroblasts / Epithelial Cells mouse monoclonal antibody, clone D7-FIB, PE

SM1214R 100 Tests Ask for price

Fibroblasts / Epithelial Cells mouse monoclonal antibody, clone D7-FIB, PE

SM1214RT 25 Tests Ask for price

Fibroblasts / Epithelial Cells mouse monoclonal antibody, clone D7-FIB, Purified

SM1214P 200 µg Ask for price

Cartilage Dissociation System 1 (Mesenchymal, Fibroblasts, Epithelial-like), Mouse and Rat

4-20231 ea Ask for price

Human Skin Cells (Fibroblasts)

ABC-TC3807 1 vial Ask for price
Description: Human fibroblasts are derived from cultured skin explants. These fibroblasts are from a single donor.

Human Primary Pulmonary Fibrosis Bronchial Epithelial Cells

T5462 1 x 10^6 / 1.0 ml Ask for price

Human Primary ∆F508/∆1152H Cystic Fibrosis Bronchial Epithelial Cells

T5425 5 x 10^5 / 1.0 ml Ask for price

Human Skin Cells (Fibroblasts, Prenata)

ABC-TC3809 1 vial Ask for price
Description: Human fibroblasts are derived from cultured skin explants. Human fibroblasts are from a single donor. These cells enable researchers to study skin diseases such as dermatitis, wound healing, and other diseases that are expressed in fibroblast. In addition, they may be used to study the development of skin and production of inducible pluripotent stem cells. Development period: Prenata

Human Skin Cells (Fibroblasts, Postnatal)

ABC-TC3808 1 vial Ask for price
Description: Human fibroblasts are derived from cultured skin explants. Human fibroblasts are from a single donor. These cells enable researchers to study skin diseases such as dermatitis, wound healing, and other diseases that are expressed in fibroblast. In addition, they may be used to study the development of skin and production of inducible pluripotent stem cells. Development period: Postnatal

Human Primary DF508/DF508 Cystic Fibrosis Bronchial Epithelial Cells

T5423 5 x 10^5 / 1.0 ml Ask for price

Human Primary DF508/N1303K Cystic Fibrosis Bronchial Epithelial Cells

T5424 5 x 10^5 / 1.0 ml Ask for price

Human Primary DF508/S549N Cystic Fibrosis Bronchial Epithelial Cells

T5427 1 x 10^6 / 1.0 ml Ask for price

Rat Lens Epithelial Cells

ABC-TC4150 1 vial Ask for price
Description: The cells that make up the mammalian lens consist of two types: lens fiber cells, which form the bulk of the lens, and a monolayer of epithelial cells cover the anterior surface of the fibers.

Rat Liver Epithelial Cells

ABC-TC4152 1 vial Ask for price
Description: Rat Liver Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Liver Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Liver Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin and ZO-1. Rat Liver Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Human Lens Epithelial Cells

ABC-TC3669 1 vial Ask for price
Description: Human Lens Epithelial Cells from Gentaur Research Laboratories are isolated from the human lens. HLEpiC are cryopreserved at primary culture and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HLEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, cytokeratin-19 and fibronectin. HLEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HLEpiC are guaranteed to further culture in the conditions provided by Gentaur Research Laboratories.

Rat Cornea Epithelial Cells

ABC-TC4115 1 vial Ask for price
Description: Rat cornea epithelial cells, 3-week Wistar rat

Rat Dermal Epithelial Cells

ABC-TC4118 1 vial Ask for price
Description: Rat Dermal Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Dermal Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Dermal Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin and ZO-1. Rat Dermal Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Kidney Epithelial Cells

ABC-TC4146 1 vial Ask for price
Description: Rat Kidney Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Kidney Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Kidney Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin or ZO-1. Rat Kidney Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Spleen Epithelial Cells

ABC-TC4221 1 vial Ask for price
Description: Rat Spleen Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Spleen Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Spleen Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin and ZO-1. Rat Spleen Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Human Oral Epithelial Cells

ABC-TC4365 1 vial Ask for price
Description: Cells are only guaranteed with purchase of Gentaur Media, Extra Cellular Matrix, Trypsin EDTA, 1X PBS, and freezing media for the appropriate cell culture, for 30 days from the date of shipment.

Human Lens Epithelial Cells

CSC-7764W One Frozen vial Ask for price

Human Nasal Epithelial Cells

ABC-TC3719 1 vial Ask for price
Description: The cells are isolated from normal human adult tissues of the airways (nasal mucosa, trachea, bronchi, and distal respiratory tract), breast (mammary gland), kidney (whole kidney and renal cortex), and the placenta (amniotic membrane). Shortly after isolation, all Gentaur Human Epithelial Cells are cryopreserved at passage 2 (P2) . Each cryo vial contains more than 500,000 viable cells after thawing. Proliferating cell cultures are made from 500,000 cryopreserved cells that have been thawed and cultured for three days at Gentaur.

Human Renal Epithelial Cells

ABC-TC3782 1 vial Ask for price
Description: Human Renal Epithelial Cells(Human kidney epithelial cells) are derived from whole kidneys that have been dissociated into single cells and purified in culture. Human kidney epithelial cells are from a single donor. These are highly purified epithelial cells as determined by specific epithelial cell markers. Human kidney epithelial cells enable researchers to study the development and biochemical function of the kidneys. In addition, they are an ideal cell for studying absorption and secretion that occurs in the kidneys. Development period: Prenatal

Rat Colonic Epithelial Cells

ABC-TC4113 1 vial Ask for price
Description: Rat Primary Colonic Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Primary Colonic Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Primary Colonic Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin or ZO-1. Rat Primary Colonic Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Corneal Epithelial Cells

ABC-TC4116 1 vial Ask for price
Description: Rat Corneal Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Corneal Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Corneal Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin or ZO-1. Rat Corneal Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Mammary Epithelial Cells

ABC-TC4166 1 vial Ask for price
Description: Rat Mammary Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Mammary Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Mammary Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin and ZO-1. Rat Mammary Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Ovarian Epithelial Cells

ABC-TC4186 1 vial Ask for price
Description: Rat Ovarian Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Ovarian Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Ovarian Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin and ZO-1. Rat Ovarian Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Stomach Epithelial Cells

ABC-TC4228 1 vial Ask for price
Description: Rat Stomach Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Stomach Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Stomach Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin or ZO-1. Rat Stomach Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Thyroid Epithelial Cells

ABC-TC4231 1 vial Ask for price
Description: Rat Thyroid Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Thyroid Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Thyroid Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin and ZO-1. Rat Thyroid Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Bladder Epithelial Cells

ABC-TC5507 1 vial Ask for price
Description: Rat Primary Bladder Epithelial Cells from Gentaur are isolated from bladder tissue of 6-8 week old laboratory Sprague–Dawley rat. Rat Primary Bladder Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 2 min and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 0.5x106 cells and is delivered frozen. The method we use to isolate primary epithelial cells was developed based on a combination of established and our proprietary methods. These cells are pre-coated with EpCAM (CD326) antibody, following the application of magnetic beads pre-coated with secondary antibody.

Human Nasal Epithelial Cells 

CSC-C1511 One Frozen vial Ask for price

Human Renal Epithelial Cells

ALHE35 1ml frozen Vial
EUR 620

Human Primary DF508/621+1G>T Cystic Fibrosis Bronchial Epithelial Cells

T5426 5 x 10^5 / 1.0 ml Ask for price

Immortalized Human Cystic Fibrosis Tracheobronchial Epithelial Cells (CFT1)

T0681 1x106 cells / 1.0 ml
EUR 686.4

Human Tonsil Epithelial Cells

ABC-TC3834 1 vial Ask for price
Description: Tonsil epithelium is a heterogeneous lymphoid organ containing two different types of actively differentiating epithelia, the lining stratified squamous epithelium and the reticulated crypt, or lymphoepithelium. The tonsil crypts represent a specialized compartment, important in the immunological functions of the tonsil because of the immediate proximity of the epithelial and lymphoid tissues. In Situ staining of tonsil epithelium suggests that expression of the simple epithelial keratins K8, K18 and K19 is located to the crypt epithelial cells. Cell culture of tonsil epithelium produces heterogeneous squamous epithelial culture in which differentiation appears to be ongoing and keratin expression patterns are consistent with those found in tonsil epithelial cells in situ. HTonEpiC from Gentaur Research Laboratories are isolated from human normal tonsil tissue. HTonEpiC are cryopreserved at passage one culture and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HTonEpiC are characterized by immunofluorescent method with cytokeratine antibodies. HTonEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HTonEpiC are guaranteed to further culture at the conditions provided by Gentaur Research Laboratories.

Porcine Lens Epithelial Cells

ABC-TC4033 1 vial Ask for price
Description: The cells that make up the mammalian lens consist of two types: lens fiber cells, which form the bulk of the lens, and a monolayer of epithelial cells that cover the anterior surface of the fibers.

Rat Prostate Epithelial Cells

ABC-TC4197 1 vial Ask for price
Description: Rat Prostate Epithelial Cells from Gentaur are isolated from tissue of adult laboratory Sprague–Dawley Rats. Rat Prostate Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Prostate Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin or ZO-1. Rat Prostate Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Tracheal Epithelial Cells

ABC-TC4233 1 vial Ask for price
Description: Rat Primary Tracheal Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Primary Tracheal Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Primary Tracheal Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin or ZO-1. Rat Primary Tracheal Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Human Thymic Epithelial Cells

ABC-TC5517 1 vial Ask for price
Description: Thymic epithelial cells (TyEpiC) are vital regulators of thymocyte development and T lymphocyte (T-cell) tolerance. The thymus contains two types of TyEpiC, cortical and medullary thymic epithelial cells, which regulate the positive selection of thymocytes and the negative selection of autoreactive T-cells. The inability of TyEpiC to remove autoreactive T-cells in the thymus can affect self-tolerance and contribute to the development of autoimmune diseases such as myasthenia gravis, type 1 diabetes, rheumatoid arthritis, and multiple sclerosis [3]. Studies have shown that changes in the expression of tumor necrosis factor receptor family members and transcription factors Foxn1 and autoimmune regulator (Aire) can alter the thymic microenvironment and self-tolerance. Human TyEpiC are an excellent in vitro model to study the mechanisms that modulate TyEpiC functionality and to develop targeted treatments for autoimmune disorders.

Human Colonic Epithelial Cells

ABC-TC3570 1 vial Ask for price
Description: The colorectum is a major organ for both malignant and nonmalignant diseases. Cells that line the colonic mucosal surface form a major mechanical barrier that separates the host’s internal milieu from the external environment. In addition to the well-established role of epithelial cells in ion transport, these cells appear to function as an integral component of the mucosal immune system. Human colon epithelial cells can process and present antigens to T cells in vitro, and can be stimulated to express HLA class II and intercellular adhesion molecules in vivo. They also respond to a broad array of cytokines with altered gene expression and growth characteristics. In addition, normal colonic epithelial cells were found to express the integrin α3, α5, α6, β1 and β4 chains. HCoEpiC from Gentaur Research Laboratories are isolated from human colonic tissue. HCoEpiC are cryopreserved at passage one and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HCoEpiC are characterized by immunofluorescent method with antibodies to CK18 and CK19. HCoEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HCoEpiC are guaranteed to further culture for 15 population doublings in the conditions provided by Gentaur Research Laboratories.

Human Corneal Epithelial Cells

ABC-TC3577 1 vial Ask for price
Description: The cornea is a unique tissue for two reasons: the transparency function and the synthesis of most of its proteins due to the cornea being an avascular tissue. The cornea consists of three distinct cell layers, the outer epithelium, the inner endothelium and the central stroma (the keratocytes). The corneal epithelium plays a role in the innate immune response by sensing the presence of pathogens and providing signals that activate the corneal defense system. It also highly expresses aldehyde dehydrogenase to protect against UV- and 4-hydroxynonenal-induced cellular damage. Corneal epithelial basal cell proliferation is controlled by a host of cytokines, e.g., epidermal growth factor, that activate their cognate receptors in the deeper layers of the epithelium. Instead of testing products in the eyes of animals, cultured corneal epithelial cells could be used for toxicology tests in in vitro models and for studying the molecular mechanisms involved in regulating human corneal epithelial cell differentiation.HCEpiC from Gentaur Research Laboratories are isolated from human cornea. HCEpiC are cryopreserved from passage one culture. Each vial contains 5×10^5 cells in 1 ml volume. HCEpiC are characterized by their cobble stone morphology in serum-free culture and immunofluorescent method with antibody to CK-18 and -19. HCEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HCEpiC are guaranteed to further expand for 10 population doublings at the condition provided by Gentaur Research Laboratories.

Human Urothel Epithelial Cells

ABC-TC3860 1 vial Ask for price
Description: The HUEPC cultures are produced on the base of human tissues. The HUEPC are isolated according to known procedures. Then primary cultures are produced. After further culturing, the HUEPC are frozen in a computer controlled freezing unit.

Rat Bronchial Epithelial Cells

ABC-TC4284 1 vial Ask for price
Description: Rat Primary Bronchial Epithelial Cells from Gentaur are isolated from bronchial tissue of 6-8 week old laboratory Sprague–Dawley rat. Rat Primary Bronchial Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 2 min and incubated in Gentaur’ Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 0.5×10^6 cells and is delivered frozen. The method we use to isolate primary epithelial cells was developed based on a combination of established and our proprietary methods. These cells are pre-coated with EpCAM (CD326) antibody, following the application of magnetic beads pre-coated with secondary antibody.

Human Bladder Epithelial Cells

ABC-TC4367 1 vial Ask for price
Description: Human Primary Bladder Epithelial Cells from Gentaur are isolated from normal human bladder tissue. Human Primary Bladder Epithelial Cells are grown in T25 tissue culture flasks pre-coated with gelatin-based coating solution for 2 min and incubated in Gentaurandrsquo; Culture Complete Growth Medium generally for 3-7 days. Cultures are then expanded. Prior to shipping, cells at passage 3 are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 0.5×10^6 cells per ml. The method we use to isolate primary epithelial cells was developed based on a combination of established and our proprietary methods. Cells are incubated with EpCAM-1 (CD326) antibody, following the application of magnetic beads pre-coated with secondary antibody.

Human Stomach Epithelial Cells

ABC-HP021X 1 vial Ask for price
Description: Human Stomach Epithelial Cells are isolated from normal human stomach tissue. Cells are cryopreserved at passage 3 and delivered frozen.

Human Colonic Epithelial Cells

CSC-C1488 One Frozen vial Ask for price

Human Stomach Epithelial Cells

CSC-C9381W One Frozen vial Ask for price

Human Corneal Epithelial Cells

cAP-0211 1Frozen Vial
EUR 594

Human Bladder Epithelial Cells

ALHE36 1ml frozen Vial
EUR 620

Immortalized Human Cystic Fibrosis Tracheobronchial Epithelial Cells-SV40

CSC-I2271Z One Frozen vial Ask for price

Human Amniotic Epithelial Cells

ABC-TC3486 1 vial Ask for price
Description: Human amniotic membrane is composed of an epithelial cell layer, a basement membrane and an avascular matrix. The amniotic epithelial cells (AEC) are formed from epiblasts on the 8th day after fertilization. A probable result of their embryonic origin, AEC lack major histocompatibility complex antigens and have been used for allotranplantation to treat patients with lysosomal diseases. Studies have shown that AEC have multiple functions such as synthesis and release of acetylcholine and catecholamine as well as expressing mRNA coding for DA receptors and DA transporters. They express neuronal and glial cell marks, produce basic fibroblast growth factors and hepatocyte growth factors and transform growth factor-beta. Human AEC has been suggested as an appropriate human cell model for studying DA release and uptake processes, receptor signal transduction and exploring newly developed drugs acting at these receptors.HAEpiC from Gentaur Research Laboratories are isolated from human amniotic membranes. HAEpiC are cryopreserved at passage one and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HAEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 and vimentin. HAEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HAEpiC are guaranteed to further expand for 15 population doublings in the condition provided by Gentaur Research Laboratories.

Human Tracheal Epithelial Cells

ABC-TC3839 1 vial Ask for price
Description: The epithelium is the interface between the body and the external environment and covers all exterior surfaces and interior lumina. Depending on the tissue of origin, the functions of epithelial cells are diverse and include absorption, secretion, protection, transcellular transport, and sensation.Gentaur offers a range of Epithelia Cells produced at Gentaur's cell culture facility. The cells are isolated from normal human adult tissues of the airways (nasal mucosa, trachea, bronchi,and distal respiratory tract), breast (mammary gland), kidney (whole kidney and renal cortex), and the placenta (amniotic membrane).Shortly after isolation, all Gentaur Human Epithelial Cells are cryopreserved at passage 2 (P2) using Gentaur's proprietary, serum-free freezing medium,Cryo-SFM. Each cryo vial contains more than 500,000 viable cells after thawing.Proliferating cell cultures are made from 500,000 cryopreserved cells that have been thawed and cultured for three days at Gentaur.

Human Prostate Epithelial Cells

ABC-TC3995 1 vial Ask for price
Description: Human Prostate Epithelial Cells (HPrEC), when grown in LIPro Medium, provides an ideal serum-free culture model, without retinoic acid, for the study of prostate cells. Common uses for HPrEC are studies of hormonal regulation of the prostate, regulation and control of the secretory function of prostate cells and as a control for the study of prostate cancer. HPrEC are cryopreserved as secondary cells to ensure the highest viability and plating efficiency. Our HPrEC are quality tested in LIPro Medium to ensure optimal serum-free growth over a period of at least 15 population doublings at rates equal to or greater than serum-supplemented media. Cell Features:HPrEC are cryopreserved as secondary cells, e.g. cells are isolated fromhuman prostate tissue and expanded twice in culture vessels before beingharvested for cryopreservation.HPrEC proliferate in a serum-free, retinoic acid-free medium withoutphenol red or antimicrobials when cultured in ProstaLifeTM medium.HPrEC are extensively tested for quality and optimal performance.Gentaur guarantees performance and quality.

Rat Esophageal Epithelial Cells

ABC-TC4133 1 vial Ask for price
Description: Rat Primary Esophageal Epithelial Cells from Gentaur are isolated from tissue of adult laboratory Sprague–Dawley Rats. Rat Primary Esophageal Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Primary Esophageal Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin or ZO-1. Rat Primary Esophageal Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Intestinal Epithelial Cells

ABC-TC4140 1 vial Ask for price
Description: Rat Intestinal Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Intestinal Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Intestinal Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin and ZO-1. Rat Intestinal Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Rat Pancreatic Epithelial Cells

ABC-TC4190 1 vial Ask for price
Description: Rat Pancreatic Epithelial Cells from Gentaur are isolated from tissue of 1-day-old neonatal laboratory Sprague–Dawley Rats. Rat Pancreatic Epithelial Cells are grown in T25 tissue culture flask pre-coated with gelatin-based coating solution for 0.5 hour and incubated in Gentaur's Cell Culture Medium for 3-5 days. Cells are detached from flasks and immediately cryo-preserved in vials. Each vial contains 1x10^6 cells and is delivered frozen.Rat Pancreatic Epithelial Cells are characterized by immunofluorescent staining with antibodies of E-cadherin and ZO-1. Rat Pancreatic Epithelial Cells are negative for bacteria, yeast, fungi, and mycoplasma. Cells can be expanded for 3-7 passages at a split ratio of 1:2 or 1:3 under the cell culture conditions specified by Gentaur. Repeated freezing and thawing of cells is not recommended.Standard biochemical procedures performed with epithelial cell cultures include the assays of cell to cell adhesion and migration, RT-PCR, Western blotting, immunoprecipitation, immunofluorescent staining or immunofluorescent flow cytometry or generating cell derivatives for desired research applications.

Human Cervical Epithelial Cells

ABC-TC5466 1 vial Ask for price
Description: Cervical Epithelial Cells have been isolated, plated, and expanded in culture vessels three times before being harvested for cryopreserved to ensure the highest purity, viability and plating efficiency. HCxEC are quality tested in Epithelial Cell Medium to ensure optimal morphology and growth over a period of at least 5 population doublings. Cervical Epithelial Cells are not exposed to antimicrobials or phenol red when cultured in Epithelial Cell Medium. Gentaur offers antimicrobials and phenol red, but they are not required for eukaryotic cell proliferation.

Human Alveolar Epithelial Cells

CSC-7845W One Frozen vial Ask for price

Human Alveolar Epithelial Cells

cAP-0208 1Frozen Vial
EUR 643.5

Human Prostate Epithelial Cells

ALHE25 1ml frozen Vial
EUR 620

Human Bronchial Epithelial Cells

ABC-TC3528 1 vial Ask for price
Description: The epithelium is the interface between the body and the external environment and covers all exterior surfaces and interior lumina. Depending on the tissue of origin, the functions of epithelial cells are diverse and include absorption, secretion, protection, transcellular transport, and sensation.Gentaur offers a range of Epithelial Cells produced at Gentaur's cell culture facility. The cells are isolated from normal human adult tissues of the airways (nasal mucosa, trachea, bronchi, and distal respiratory tract), breast (mammary gland), kidney (whole kidney and renal cortex), and the placenta (amniotic membrane).Shortly after isolation, all Gentaur Human Epithelial Cells are cryopreserved at passage 2 (P2) using Gentaur's proprietary, serum-free freezing medium, Cryo-SFM. Each cryo vial contains more than 500,000 viable cells after thawing.Proliferating cell cultures are made from 500,000 cryopreserved cells that have been thawed and cultured for three days at Gentaur.

Human Placental Epithelial Cells

ABC-TC3753 1 vial Ask for price
Description: The epithelium is the interface between the body and the external environment and covers all exterior surfaces and interior lumina. Depending on the tissue of origin, the functions of epithelial cells are diverse and include absorption, secretion, protection, transcellular transport, and sensation.Gentaur offers a range of Epithelial Cells produced at Gentaur's cell culture facility. The cells are isolated from normal human adult tissues of the airways (nasal mucosa, trachea, bronchi, and distal respiratory tract), breast (mammary gland), kidney (whole kidney and renal cortex), and the placenta (amniotic membrane).Shortly after isolation, all Gentaur Human Epithelial Cells are cryopreserved at passage 2 (P2) using Gentaur's proprietary, serum-free freezing medium, Cryo-SFM. Each cryo vial contains more than 500,000 viable cells after thawing.Proliferating cell cultures are made from 500,000 cryopreserved cells that have been thawed and cultured for three days at Gentaur.

Porcine Corneal Epithelial Cells

ABC-TC4029 1 vial Ask for price
Description: The cornea is a unique tissue for two reasons: the transparency function and the synthesis of most of its proteins due to the cornea being an avascular tissue.

Canine Alveolar Epithelial Cells

ABC-TC5511 1 vial Ask for price
Description: Canine Primary Alveolar Epithelial Cells are isolated from alveolar tissue of beagle dog. Canine Primary Alveolar Epithelial Cells are grown in a T25 tissue culture flask pre-coated with gelatin-based coating solution for 2 min and incubated in Culture Complete Growth Medium for 3-5 days. Prior to shipping, cells at passage 2 are detached from flasks and immediately cryo-preserved in vials. Each vial contains at least 0.5x106 cells per ml and is delivered frozen. The method we use to isolate primary epithelial cells was developed based on a combination of established and our proprietary methods.

Human Laryngeal Epithelial Cells

ABC-TC5518 1 vial Ask for price
Description: Laryngeal Epithelial Cells are cultured without retinoic acid and cryopreserved as primary cells to ensure the highest viability and plating efficiency.

Retinal Pigment Epithelial Cells

RPE001 500,000 Cells
EUR 1545.6

Human Bronchial Epithelial Cells

CSC-C4388X One Frozen vial Ask for price

Human Bronchial Epithelial Cells

ALHE47 1ml frozen Vial
EUR 620

Immortalized Human Pulmonary Fibroblasts Cells

T0490 1x106 cells / 1.0 ml
EUR 2750

Immortalized Human Pulmonary Fibroblasts Cells

CSC-I9127L One Frozen vial Ask for price

Human Esophageal Epithelial Cells

ABC-TC3612 1 vial Ask for price
Description: The human esophagus is lined by a non-keratinizing, moist stratified squamous epithelium whose apical cell membranes and intercellular junctional complexes combine to produce an effective permeability barrier against the influx of luminal content. In particular, the barrier created by these structures limits exposure of the surface cells' basolateral cell membranes and entire membrane of cells of the deeper layers to the wide swings in osmolality occurring regularly within the esophageal lumen. Histologically, the esophageal epithelium consists of two zones, the basal and differentiated zones. Cellular proliferation is limited to the basal zone, and cells are thought to migrate from this area towards the esophageal lumen. Migration is associated with the initiation of differentiation and the sequential expression of differentiation markers. The availability of human esophageal epithelial cell culture provides an excellent in vitro model in the study of the physiology of esophageal epithelium and the mechanisms of the esophageal carcinogenesis.HEEC from Gentaur Research Laboratories are isolated from the human esophagus. HEEC are cryopreserved on passage one culture and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HEEC are characterized by immunofluorescent method with antibodies to cytokeratine-8, -18 and -19. HEEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HEEC are guaranteed to further expand for 15 population doublings in the condition provided by Gentaur Research Laboratories.

Human Pancreatic Epithelial Cells

ABC-TC3744 1 vial Ask for price
Description: Human Pancreatic Epithelial Cell were initiated by elutriation of dispase dissociated normal pancreatic tissue.These cells were originated using Complete Serum-Free Medium Kit With AcceSup™, are available at <12 Cumulative Population Doublings (CPD) in vitro [Passage 3] and were cryopreserved in aliquots of ~1.5×10^6 cells. This vial will initiate a Passage 4 cell culture in a 75cm2 flask.

Human Intestinal Epithelial Cells

ABC-TC3879 1 vial Ask for price
Description: Cryopreserved InEpC are truly primary cells representing both villi (enterocytes, goblet, and enteroendocrine cells) and crypts structures. In combination with human intestinal myofibroblasts (InMyoFib).

Human Esophageal Epithelial Cells 

CSC-7783W One Frozen vial Ask for price

Human Pancreatic Epithelial Cells

CSC-8246W One Frozen vial Ask for price

Human Endometrial Epithelial Cells

ABC-TC4601 1 vial Ask for price
Description: Proliferation and Morphology: Normal morphology for 5 population doublings, minimum 70% viability when thawed from cryopreservation. Normal Human Endometrial (Uterine) Epithelial Cells provide an ideal serum-free culture model for many areas of research. These cells may be used to study cellular physiology of the reproductive tract, the cellular response to infectious agents, and other areas of research, Endometrial Epithelial Cells have been isolated, plated, and expanded in culture vessels three times before being harvested for cryopreservation to ensure the highest purity, viability and plating efficiency.

Human Conjunctival Epithelial Cells

ABC-TC3573 1 vial Ask for price
Description: The conjunctival epithelium is a stratified, non-keratinized epithelium. It can be distinguished by the corneal epithelium by the expression of different cytokeratins, mucins and by the presence of glycocalix. Decrease or loss of mucin/glycocalix production generates squamous metaplasia, which may lead to dry eye and ocular surface diseases. Human conjunctival epithelial cells represent potential target cells for mast cell mediators. They respond to histamine by generating inositol phosphates, mobilizing intracellular calcium, and then secreting proinflammatory cytokines like interleukin-6 and interleukin-8.HConEC from Gentaur Research Laboratories are isolated from human conjunctiva. HConEC are cryopreserved from passage one culture. Each vial contains 5×10^5 cells in 1 ml volume. HConEC are characterized by their cobble stone morphology in serum-free culture and immunofluorescent method with antibody to CK-18 and -19. HConEC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HConEC are guaranteed to further expand for 10 population doublings at the condition provided by Gentaur Research Laboratories.

Bovine Endometrium Epithelial Cells

ABC-TC3131 1 vial Ask for price
Description: Bovine Endometrial Epithelial Cells (BEnEpC) are isolated from epithelium of the bovine endometrium. The cells are cryopreserved at second passage. BEnEpC can be cultured and propagated for at least 10 population doublings.

Human Conjunctival Epithelial Cells 

CSC-7802W One Frozen vial Ask for price

Human Dermal Fibroblasts-fetal Feeder Cells

T2002 10^6 cells/1.0 ml
EUR 200

Epithelial Dissociation System 11 (Epithelial Cells), Mouse and Rat

4-20261 ea Ask for price

Rat Primary Lung Epithelial Cells

T4800 5x10^5 cells / 1.0 ml
EUR 625

Human Nasopharyngeal Epithelial Cells

cAP-0222 1Frozen Vial
EUR 4455

Rat Renal Tubular Epithelial Cells

ABC-TC4210 1 vial Ask for price
Description: Renal tubular epithelial cells (RTEpiC) play a crucial role in renal function. They reabsorb nearly all of the glucose and amino acids in the glomerular filtrate, while allowing other substances of no nutritional value to be excreted in the urine.

Human Renal Mixed Epithelial Cells

ABC-TC4245 1 vial Ask for price
Description: Normal Human Renal Epithelial Cells, when grown in LIRen Medium, provide an ideal low-serum culture model for the study of renal function, metabolism, nephrotoxicity or cancer research. Renal Mixed Epithelial Cells are cryopreserved as primary cells to ensure the highest viability and plating efficiency. Our Renal Epithelial Cells are quality tested in LIRen Medium to ensure optimal reduced-serum growth over a period of at least 15 population doublings at rates equal to or greater than serum-supplemented medium. Cell Features:Mixed Renal Epithelial, Renal Cortical Epithelial, and Renal Medullary Epithelial are cryopreserved as primary cells isolated from human kidney tissue and expanded in culture vessels once before cryopreservation.Renal Proximal Tubule Epithelial are cryopreserved as secondary cells isolated from human kidney tissue and expanded in culture vessels twice before cryopreservation.All Renal Epithelial Cell types can be grown in a 0.5% serum medium without phenol red or antimicrobials when cultured in LIRen Medium.All Renal Epithelial Cell types are extensively tested for quality and optimal performance.Gentaur guarantees performance and quality.

Rat Primary Renal Epithelial Cells

T4936 5x10^5 cells / 1.0 ml Ask for price

Human Iris Pigment Epithelial Cells

ABC-TC3658 1 vial Ask for price
Description: The iris is a pigmented disk with a variable aperture which forms the pupil of the eye. It is covered by squamous epithelium on anterior surface and 2 layers of pigmented epithelium on posterior. The iris pigment epithelial cells (IPE) share functional properties with retinal pigment epithelial cells (RPE) such as phagocytosis, degradation of rod outer segments and synthesis of trophic factors. In recent years, IPE have been transplanted into the subretinal space of eye to treat RPE defects. The grafted IPE were seen to survive for months. There was a remodeling of cellular layers in the subretinal space over time where grafted IPE joined the native RPE. The cellular response that developed exhibited macrophages and were similar to that observed following RPE transplantation. In vitro study also show that IPE expressing CD86, directly suppresses T cell activation via binding to cytotoxic T lymphocyte-associated antigen 4.HIPEpiC from Gentaur Research Laboratories are isolated from the human iris. HIPEpiC are cryopreserved at passage one and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HIPEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, vimentin and fibronectin. HIPEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HIPEpiC are guaranteed to further expand for two passages (around 10 population doublings) in the conditions provided by Gentaur Research Laboratories.

Human Mammary Epithelial Cells, Male

ABC-TC3693 1 vial Ask for price
Description: Human Mammary Epithelial Cells, when grown in LIMam Medium, provide an ideal serum-free culture model for many areas of research. Common uses of HMEC include the study of breast cancer development, three dimensional culture and carcinogen screening.Cell Features:HMEC are cryopreserved as tertiary cells, e.g. cells are isolated from human mammary tissue and expanded three times in culture vessels before being harvested for cryopreservation.HMEC are extensively tested for quality and optimal performance.Gentaur guarantees performance and quality.

Human Small Airway Epithelial Cells

ABC-TC3811 1 vial Ask for price
Description: The small airways are located at the interface between alveoli and conducting airways. Airway epithelial cells forming a continuous lining to the airways play a unique role as a protective physical and functional barrier to external deleterious agents. These cells function in the regulation of immune responses by contributing to host defense through chemokine production, adhesion molecule expression, and possibly antigen presentation via HLA-DR expression. They also produce liquids contributing to pulmonary fluid balance. Many airway diseases, such as asthma, bronchiolitis, chronic obstructive pulmonary disease, and cystic fibrosis, involve damage to the airway surface epithelium. The human small airway epithelial cell culture may identify new therapeutic options in preventing amplified airway ailment and remodeling.HSAEpiC from Gentaur Research Laboratories are isolated from human lung tissue. HSAEpiC are cryopreserved at either primary culture or passage one culture and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HSAEpiC are characterized by immunofluorescent method with antibodies CK-18, -19, and vimentin. HSAEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HSAEpiC are guaranteed to further expand for 15 population doublings at the conditions provided by Gentaur Research Laboratories.

Human Small Airway Epithelial Cells

CSC-C9229J One Frozen vial Ask for price

Human Small Airway Epithelial Cells

ALHE50 1ml frozen Vial
EUR 620

Human Mammary Basal Epithelial Cells

ABC-TC3690 1 vial Ask for price
Description: human mammary basal epithelial cells are isolated from mammary tissue of healthy non-diabetic donors between 18 and 60 years old who have undergone elective surgery. The cells are isolated by digestion of the tissue to generate organoid structures.

Human Mammary Epithelial Cells, Adult

ABC-TC3691 1 vial Ask for price
Description: The mammary gland consists of pseudostratified epithelia, with myoepithelila cells resting upon a basement membrane and apical glandular epithelial cells facing the lumen of the ducts and alveoli. Mammary epithelial cells undergo changes in growth, invasion, and differentiation throughout much of adulthood, and most strikingly during pregnancy, lactation, and involution. They proliferate and invade the surrounding extracellular matrix during the fetal and postnatal development of the gland, and then more vigorously at puberty as the branches of the mammary epithelial tree are formed.HMEpiC from Gentaur Research Laboratories are isolated from normal human breast tissue. HMEpiC are cryopreserved at passage one culture and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HMEpiC are characterized by immunofluorescent method with cytokeratine antibodies. HMEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HMEpiC are guaranteed to further expand for 15 population doublings in the conditions provided by Gentaur Research Laboratories

Human Primary Nasal Epithelial Cells

T4014 5x10^5 cells / 1.0 ml
EUR 1375

Human Primary Renal Epithelial Cells

T4090 5x10^5 cells / 1.0 ml Ask for price

Rat Primary Bladder Epithelial Cells

T4940 5x10^5 cells / 1.0 ml Ask for price

GFP-Human Corneal Epithelial Cells

cAP-0211GFP 1Frozen Vial
EUR 841.5

Primary Rabbit Retinal Pigment Epithelial Cells (RPEC)

CSI146Rb01 5X10^5
EUR 1760

Human Choroid Plexus Epithelial Cells

ABC-TC3568 1 vial Ask for price
Description: The choroid plexus epithelial cells (CPEpiC) are the structural basis, form a selective barrier between the nervous system and the blood, and secrete cerebrospinal fluid into the ventricles of the brain. CPEpiC express inward-rectifying anion channels which are thought to have an important role in the secretion of cerebrospinal fluid. CPEpiC synthesize and secrete many growth factors and other peptides that are of trophic benefit following injury to regions of the cerebroventricular system. For example, several growth factors are upregulated in choroid plexus after ischemic and traumatic insults to the central nervous system. The presence of numerous types of growth factor receptors in choroid plexus allows growth factor mediation of recovery processes by autocrine and paracrine mechanisms. CPEpiC culture has been widely used to evaluate their morphological and physiological properties, and its capacity to serve as an in vitro model to access the cellular mechanisms of organic cation transport across the cerebrospinal fluid-blood barrier.HCPEpiC from Gentaur Research Laboratories are isolated from human choroid plexus. HCPEpiC are cryopreserved after purification and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HCPEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 and vimentin. HCPEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HCPEpiC are guaranteed to further expand for 15 population doublings in the conditions specified by Gentaur Research Laboratories.

Human Mammary Epithelial Cells, Female

ABC-TC3692 1 vial Ask for price
Description: Human Mammary Epithelial Cells, when grown in LIMam Medium, provide an ideal serum-free culture model for many areas of research. Common uses of HMEC include the stages of breast cancer development, three dimensional culture and carcinogen screening.Cell Features:HMEC are cryopreserved as tertiary cells, e.g. cells are isolated from human mammary tissue and expanded three times in culture vessels before being harvested for cryopreservation.HMEC are extensively tested for quality and optimal performance.Gentaur guarantees performance and quality.

Human Renal Cortical Epithelial Cells

ABC-TC4242 1 vial Ask for price
Description: Renal epithelial cells (REpiC) play a crucial role in renal function. Similar to most other epithelial cells, renal epithelial cells display a polarized morphology which is essential for their function. They reabsorb nearly all of the glucose and amino acids in the glomerular filtrate, while allowing other substances of no nutritional value to be excreted in the urine. Human REpiC are capable of internalizing bacteria. They are also a major site of injury in a variety of congenital, metabolic, and inflammatory diseases. REpiC can produce inflammatory mediators such as cytokines and chemokines and actively participate in acute inflammatory processes by affecting and directing leukocyte chemotaxis via the production of IL-8. REpiC express IL-2R alpha and MHC class II antigens during inflammation, indicating their capacity to participate in the pathogenesis of immune renal injury. To be able to study the relationship between renal epithelial cells and a variety of renal diseases, the HREpiC culture provides a useful in vitro model.HRCEpiC from Gentaur Research Laboratories are isolated from human kidneys. HRCEpiC are cryopreserved at passage one and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HRCEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, -19 and vimentin. HRCEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HRCEpiC are guaranteed to further expand for 15 population doublings in the condition provided by Gentaur Research Laboratories.

Human Fallopian Tube Epithelial Cells

ABC-TC5521 1 vial Ask for price
Description: Fallopian Tube Epithelial Cells have been isolated, plated and expanded in culture vessels three times before being harvested for cryopreservation to ensure the highest viability and plating efficiency. Fallopian Tube Cells are quality tested in our Medium to ensure optimal morphology and growth over a period of at least 5 population doublings.

Rat Primary Cervical Epithelial Cells

T4952 5x10^5 cells / 1.0 ml Ask for price

Rat Primary Prostate Epithelial Cells

T4956 5x10^5 cells / 1.0 ml Ask for price

Human Primary Thymic Epithelial Cells

T4980 5x10^5 cells / 1.0 ml
EUR 975

Rat Primary Tracheal Epithelial Cells

T4804 5x10^5 cells / 1.0 ml Ask for price

Human Renal Cortical Epithelial Cells

cAP-0139 1Frozen Vial
EUR 693

Human Choroid Plexus Epithelial Cells.

cAP-0213 1Frozen Vial
EUR 445.5

Human Large Intestine Epithelial Cells

ABC-TC3667 1 vial Ask for price
Description: This cell line is available in limited quantities. Please contact us for more information.

Human Mammary Luminal Epithelial Cells

ABC-TC3695 1 vial Ask for price
Description: Human Mammary Luminal Epithelial Cell

Human Ovarian Surface Epithelial Cells

ABC-TC3743 1 vial Ask for price
Description: The human ovary is covered with a single layer of flat to cuboidal surface epithelial cells (OSE). OSE are physiologically involved in follicular rupture and the subsequent repair of the follicle wall during reproductive age. OSE exhibit a gland formation in coculture with endometrial stromal cells in an estrogen-rich environment. The phenotypic plasticity of these cells shares a mesenchymal property when they are cultured on two layers of extracellular matrix and collagen gel. OSE are the source of epithelial ovarian carcinomas. Understanding the mechanisms that regulate OSE cell survival, apoptosis, and cell growth is of great clinical importance because an aberrant signaling of any of these pathways is likely to be involved in epithelial ovarian cancer.HOSEpiC from Gentaur Research Laboratories are isolated from human ovarian tissue. HOSEpiC are cryopreserved either at primary or passage one cultures and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HOSEpiC are characterized by immunofluorescent method with cytokeratine antibodies (CK-14, -18 and -19). HOSEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HOSEpiC are guaranteed to further expand for over 5 population doublings in the conditions provided by Gentaur Research Laboratories.

Human Retinal Pigment Epithelial Cells

ABC-TC3791 1 vial Ask for price
Description: The human retina is a multi-layered structure lining the rear of the eye. It consists of photoreceptor cells and retinal pigment epithelial cells (RPE). RPE situated between the neurosensory retina and the choroid, form the outer blood-retina barrier that controls the chemical composition of the subretinal space. RPE has long been recognized to differ from many other epithelia in the polarity of a number of proteins and whereas almost all other epithelia face an apical lumen devoid of matrix, the RPE apical plasma membrane is in contact with the extracellular matrix. During early embryonic development, RPE spontaneously transdifferentiate into neural retinal tissue. RPE play a critical role in the development and maintenance of adjacent photoreceptors. They generate a number of reactive oxygen species when illuminated with light and their proliferation is an important step in the pathogenesis of ocular diseases such as proliferative retinopathy. HRPEpiC from Gentaur Research Laboratories are isolated from human retina. HRPEpiC are cryopreserved at passage one and delivered frozen. Each vial contains 5×10^5 cells in 1 ml volume. HRPEpiC are characterized by immunofluorescent method with antibodies to cytokeratin-18, cytokeratin-19 and fibronectin. HRPEpiC are negative for HIV-1, HBV, HCV, mycoplasma, bacteria, yeast and fungi. HRPEpiC are guaranteed to further expand for 15 population doublings in the condition provided by Gentaur Research Laboratories.

Human Seminal Vesicle Epithelial Cells

ABC-TC3795 1 vial Ask for price
Description: Special edition cells are isolated from the tissue types described. Cells are sterility and virus tested. All tissues used for cell isolation are obtained under informed consent. Gentaur complies with the U.S. Health Insurance Portability and Accountability Act (HIPAA). Characterization standards for special edition cells have not been established.

La microrhéologie basée sur des sondes magnétiques révèle un ramollissement et une rigidification locaux des matrices de collagène 3D par les fibroblastes

  • Modifications in extracellular matrix stiffness affect quite a lot of organic processes together with most cancers development. Nonetheless, cells additionally actively rework the matrices they work together with, dynamically altering the matrix mechanics they reply to. Additional, cells not solely react to matrix stiffness, but additionally have a definite response to matrix viscoelasticity. The affect of cell-driven matrix reworking on matrix stiffness and viscoelasticity on the microscale stays unclear, as current strategies to measure mechanics are largely on the bulk scale or probe solely the floor of matrices, and deal with stiffness.
  • But, establishing the affect of the matrix reworking on the microscale is essential to acquiring an understanding of mechanotransduction in organic matrices, and organic matrices will not be simply elastic, however are viscoelastic. Right here, we superior magnetic probe-based microrheology to beat its earlier limitations in measuring viscoelasticity on the cell-size-scale spatial decision inside 3D cell cultures which have tissue-relevant stiffness ranges as much as a Younger’s modulus of 0.5 kPa.
  • Our magnetic microrheometers exert managed magnetic forces on magnetic microprobes inside reconstituted extracellular matrices and detect microprobe displacement responses to measure matrix viscoelasticity and decide the frequency-dependent shear modulus (stiffness), the loss tangent, and spatial heterogeneity. We utilized these instruments to examine how microscale viscoelasticity of collagen matrices is altered by fibroblast cells as they contract collagen gels, a course of studied extensively on the macroscale.
  • Curiously, we discovered that fibroblasts first soften the matrix domestically over the primary 32 hours of tradition, after which progressively stiffen the matrix thereafter. Fibroblast exercise additionally progressively elevated the matrix loss tangent. We confirmed that the softening is brought on by matrix-metalloproteinase-mediated collagen degradation, whereas stiffening is related to native alignment and densification of collagen fibers across the fibroblasts. This work paves the way in which for the usage of measurement techniques that quantify microscale viscoelasticity inside 3D cell cultures for research of cell-matrix interactions in most cancers development and different areas.Les agonistes des récepteurs de la dopamine améliorent la fibrose pulmonaire induite par la bléomycine en réprimant la différenciation et la prolifération des fibroblastes 

Idiopathic pulmonary fibrosis (IPF) is the commonest deadly interstitial lung illness, with restricted therapeutic choices. The irregular and uncontrolled differentiation and proliferation of fibroblasts have been confirmed to play a vital function in driving the pathogenesis of IPF. Due to this fact, efficient and well-tolerated antifibrotic brokers that intervene with fibroblasts can be a really perfect remedy, however no such therapies can be found. Remarkably, we discovered that dopamine (DA) receptor D1 (D1R) and DA receptor D2 (D2R) have been each upregulated in myofibroblasts in lungs of IPF sufferers and a bleomycin (BLM)-induced mouse mannequin.

Then, we explored the protection and efficacy of DA, fenoldopam (FNP, a selective D1R agonist) and sumanirole (SMR, a selective D2R agonist) in reversing BLM-induced pulmonary fibrosis. Additional knowledge confirmed that DA receptor agonists exerted potent antifibrotic results in BLM-induced pulmonary fibrosis by attenuating the differentiation and proliferation of fibroblasts. Detailed pathway evaluation revealed that DA receptor agonists decreased the phosphorylation of Smad2 induced by TGF-β1 in major human lung fibroblasts (PHLFs) and IMR-90 cells. Total, DA receptor agonists protected mice from BLM-induced pulmonary fibrosis and could also be therapeutically useful for IPF sufferers in a medical setting.

Le transcriptome altéré et le phénotype lié à la maladie n’apparaissent qu’après différenciation des fibroblastes prélevés sur des sufferers atteints de dégénérescence maculaire liée à l’âge en épithélium pigmentaire rétinien

  •  We have now reported beforehand that retinal pigment epithelium (RPE) differentiated from induced pluripotent stem cells (iPSC) generated from fibroblasts of sufferers with age-related macular degeneration (AMD) exhibit a retinal degenerative illness phenotype and a definite transcriptome in comparison with age-matched controls. Because the genetic composition of the iPSC and RPE are inherited from fibroblasts, we investigated whether or not differential habits was current within the parental fibroblasts and iPSC previous to differentiation of the cell traces into RPE. Principal part analyses revealed important overlap (primarily no variations) within the transcriptome of fibroblasts between AMD and controls.
  • After reprogramming, there was no important distinction within the transcriptome of iPSC generated from AMD versus regular donors. In distinction, the transcriptome of RPE derived from iPSC segregated into two distinct clusters of AMD-derived cells versus controls. Curiously, mitochondrial dysfunction in AMD-derived RPE was evident after roughly two months in tradition. Furthermore, these variations in mitochondrial dysfunction weren’t evident within the parental fibroblasts and iPSC.
  • This research demonstrates an altered transcriptome and impaired mitochondrial perform in RPE derived from AMD sufferers versus controls, and demonstrates these variations will not be current within the authentic fibroblasts or iPSC. These outcomes counsel that pathology in AMD is triggered upon differentiation of mother or father cells into RPE. Extra research of this phenomenon might advance the present understandings of the etiology of AMD and the event of novel therapeutic targets.

 

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