Le knockdown de Fus inhibe l’effet profibrogène

Le knockdown de Fus inhibe l’effet profibrogène des fibroblastes cardiaques induits par l’angiotensine II en ciblant Pax3, régulant ainsi la voie TGF- / 1 / Smad

 The Angiotensin II/transforming growth factor-β1 (AngII/TGF-β1) signal axis is an important regulatory pathway for atrial fibrosis, which can contribute to atrial fibrillation (AF). Fused in sarcoma (FUS) was recently found to regulate cardiac diseases. This study aimed to investigate whether FUS could regulate AngII induced fibrosis and uncover the possible mechanisms. The expression of FUS in AF patients and AngII-induced cardiac fibroblasts was measured by RT-qPCR and western blot assays. Fus was silenced in cells using short hairpin RNA (shRNA), then cell proliferation, migration, collagen synthesis and TGF-β1/Smad signaling were detected by CCK-8, wound healing and western blot assays, respectively. The possible target for Fus was predicted by searching Starbase database and verified by RNA-binding protein immunoprecipitation (RIP) and RNA pull down.

Cells were overexpressed with Pax3 in the presence of Fus silence and AngII stimulation, then the above cellular processes were further evaluated. Results showed that FUS was upregulated in AF patients and AngII-induced cardiac fibroblasts. Fus knockdown inhibited AngII-enhanced cell proliferation, migration, collagen synthesis and TGF-β1/Smad signaling activation. Furthermore, Fus functions as an RNA-binding protein to bind to Pax3 mRNA and positively regulate its expression. Further studies demonstrated that Pax3 overexpression canceled the above effects of Fus knockdown on cell proliferation, migration, collagen synthesis, and TGF-β1/Smad signaling activation in AngII-induced cells. In conclusion, Fus could target Pax3 to increase the pro-fibrotic effect of AngII in cardiac fibroblasts via activating TGF-β1/Smad signaling. Knockdown of Fus/Pax3 axis may provide a potential therapy for relieving AF.

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STJ117206 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Anti-Anti-SEPT12 Antibody antibody
STJ117759 100 µl
EUR 277
Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.
Anti-Anti-MARCH6 Antibody antibody
STJ118549 100 µl
EUR 277
Anti-Anti-MARCH6 Antibody antibody
STJ118550 100 µl
EUR 277
Anti-Anti-MARCH7 Antibody antibody
STJ118752 100 µl
EUR 277
Anti-Anti-SEPT3 Antibody antibody
STJ118990 100 µl
EUR 277
Anti-Anti-SEPT1 antibody antibody
STJ119580 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]
Cytokeratin 7 antibody-Cytoskeleton Marker Antibody
48169-100ul 100ul
EUR 333

L’acide salvianolique B inhibe la différenciation des myofibroblastes et l’accumulation de matrice extracellulaire dans les fibroblastes polypes nasaux via la voie de signalisation TGF-sign1 

In the process of nasal tissue remodeling, nasal fibroblasts serve an important role via myofibroblast differentiation and the production of extracellular matrix (ECM). Nasal fibroblast abnormalities can lead to conditions such as chronic rhinosinusitis. Salvianolic acid B (Sal B), a water-soluble active pharmaceutical compound extract from the root of the traditional Chinese medicine Salvia miltiorrhiza, displays antioxidative, antiproliferative and antifibrosis properties. The present study aimed to investigate the mechanism underlying the effects of Sal B on nasal polyp fibroblast (NPF) myofibroblast differentiation and ECM accumulation. Primary NPFs were obtained from nasal polyps of patients with chronic sinusitis. The proliferative and cytotoxic effects of Sal B on NPFs were evaluated by performing the Cell Counting Kit-8 assay.

The Transwell assay was conducted to assess cell migration. α-smooth muscle actin (α-SMA), TGF-β1 receptor (TβR)-I, TβR-II, Smad2/3 mRNA and protein expression levels and (p)-Smad2/3 phosphorylation levels were measured via reverse transcription-quantitative PCR and western blotting, respectively. Type III collagen and fibronectin levels were analyzed by ELISA. The results indicated that Sal B significantly downregulated TGF-β1-induced α-SMA, fibronectin and collagen III expression levels in NPFs. Similarly, Sal B significantly decreased TGF-β1-induced TβR-I, TβR-II, p-Smad2/3, MMP-2 and MMP-9 mRNA and protein expression levels in NPFs. Furthermore, Sal B significantly decreased TGF-β1-induced NPF migration. Therefore, the present study indicated that Sal B inhibited myofibroblast differentiation and ECM accumulation in nasal fibroblasts, suggesting that Sal B may inhibit nasal polyp formation via certain mechanisms.

E2F2 stimule l’expression de CCR4 et active les cellules de type fibroblaste synovial dans la polyarthrite rhumatoïde 

Aim of the study: E2F transcription factor 2 (E2F2) has increased expression in synovial tissues of rheumatoid arthritis (RA) and stimulates interleukin (IL)-1 α and IL-β production in cultured RA synovial fibroblast-like cells (RASF), which supports the importance of E2F2 in RA pathogenesis. This study investigated the effect and mechanism of E2F2 in RA.

Material and methods: Cultured RASF were transfected with anti-E2F2 siRNA, and the expression profile was analyzed with an inflammatory response and autoimmunity PCR array loaded with 84-relative genes to explore the pathogenic pathway of E2F2. Apoptosis, migration and tube-like structure formation in the RASF with transfection of anti-E2F2 siRNA or E2F2-expressing plasmids were examined using flow cytometry, transwell assays and Matrigel assays, respectively.

Results: Significantly decreased expression of chemokine receptor 4 (CCR4) was detected in RASF with inhibited E2F2 expression, and the CCR4 expression was increased in RASF with transfection of E2F2-expressing plasmids. Silencing E2F2 expression stimulated apoptosis, but retarded migration and tube-like structure formation in RASF. The opposite observation was obtained in RASF with E2F2 overexpression.

Conclusions: High E2F2 expression decreases apoptosis and increases migration and tube-like structure ability in RASF and might perform this role by up-regulating CCR4 expression, which ultimately contributes to the disease progression of RA synovial tissues.

Taux de sécrétion et composition protéique des vésicules extracellulaires libérées par les fibroblastes associés au cancer après irradiation 

Reciprocal communication between the malignant and non-malignant cellular elements in tumors is essential for cancer sustainability and plays an important role in the response of cancers to treatments. Some of this cellular crosstalk takes place via secretion of vesicles that are actively released into the extracellular space by most cell types in tumors. Recent studies have demonstrated radiation-induced changes in the secretion rate and composition of extracellular vesicles (EVs), with impact on radiation-related cellular communication.

However, little is known about the effects of different radiation regimens on the release of EVs by cells of the tumor microenvironment. In this study, we provide a comprehensive molecular characterization of EVs released by cultured primary lung tumor fibroblasts. We explore the quantitative and morphological changes triggered by ionizing radiation (IR), delivered as a single dose of 18 Gy or three consecutive daily medium-doses of 6 Gy. Cancer-associated fibroblasts (CAFs) secrete EVs with sizes ranging from 80 to 200 nm, expressing some of the classical exosome markers. Exposing CAFs to a single-high radiation dose (1 × 18 Gy) or fractionated medium-dose did not alter the release of CAF-EVs.

The protein composition of CAF-EVs was analyzed by LC-MS/MS proteomics and revealed that CAF-EVs are enriched with heat shock proteins, integrins, tetraspanins, proteinases, collagens, growth factors and an array of molecules involved in the regulation of cell migration and the immune system. Quantitative proteomic analyses revealed minor changes in the protein composition of CAF-EVs after radiation exposure. Taken together, this study presents original data on lung tumor CAF-EV composition and reveals that release and protein cargo of CAF-EVs are largely unaltered after exposing CAFs to IR.

TIMP-2, human fibroblasts

7788-5
EUR 338

FBS, Fibroblasts Optimized I

F0691-050 500ml Ask for price

Human Fibroblasts-GFP Expressing

GFP07 500,000 Cells in T25 flask
EUR 1354

Immortalized Human Cardiac Fibroblasts

T0446 1x106 cells / 1.0 ml Ask for price

Immortalized Human Uterine Fibroblasts

T0610 1x106 cells / 1.0 ml Ask for price

Human Cancer PrimaCell7: Esophageal Fibroblasts

2-96030 1 Kit Ask for price

Immortalized Human Gingival Fibroblasts- hTERT

T0026 1x106 cells / 1.0 ml Ask for price

Immortalized Human Mammary Fibroblasts (HMF3A)

T0153 1x106 cells / 1.0 ml Ask for price

Immortalized Human Mammary Fibroblasts (HMF3S)

T0154 1x106 cells / 1.0 ml Ask for price

Immortalized Human Neonatal Fibroblasts - hTERT

T0344 1x106 cells / 1.0 ml Ask for price

Immortalized Rat Embryonic Fibroblasts (18IM)

T0354 1x106 cells / 1.0 ml Ask for price

Immortalized Human Pulmonary Fibroblasts Cells

T0490 1x106 cells / 1.0 ml Ask for price

Immortalized Human Corneal Fibroblasts (IHCF)

T0578 1x106 cells / 1.0 ml Ask for price

Immortalized Human Diploid Fibroblasts - hTERT

T1013 1x106 cells / 1.0 ml Ask for price

Mouse Bladder PrimaCell2: Normal Bladder Fibroblasts

2-82007 1 Kit Ask for price

Mouse Brain PrimaCell1: Normal Brain Fibroblasts

2-82010 1 Kit Ask for price

Mouse Cervix PrimaCell2: Normal Cervical Fibroblasts

2-82024 1 Kit Ask for price

Mouse Eye PrimaCell3: Normal Corneal Fibroblasts

2-82039 1 Kit Ask for price

Mouse Heart PrimaCell3: Normal Heart Fibroblasts

2-82047 1 Kit Ask for price

Mouse Lung PrimaCell2: Normal Lung Fibroblasts

2-82065 1 Kit Ask for price

Mouse Lymph PrimaCell3: Normal Lymphatic Fibroblasts

2-82073 1 Kit Ask for price

Rat Bladder PrimaCell2: Normal Bladder Fibroblasts

2-82507 1 Kit Ask for price

Rat Brain PrimaCell1: Normal Brain Fibroblasts

2-82511 1 Kit Ask for price

Rat Cervix PrimaCell2: Normal Cervical Fibroblasts

2-82525 1 Kit Ask for price

Rat Eye PrimaCell3: Normal Corneal Fibroblasts

2-82540 1 Kit Ask for price

Rat Heart PrimaCell3: Normal Heart Fibroblasts

2-82548 1 Kit Ask for price

Rat Lung PrimaCell1: Normal Lung Fibroblasts

2-82564 1 Kit Ask for price

Rat Lymph PrimaCell3: Normal Lymphatic Fibroblasts

2-82572 1 Kit Ask for price

Human Bladder PrimaCell2: Normal Bladder Fibroblasts

2-96008 1 Kit Ask for price

Human Brain PrimaCell1: Normal Brain Fibroblasts

2-96013 1 Kit Ask for price

Human Cervix PrimaCell2: Normal Cervical Fibroblasts

2-96045 1 Kit Ask for price

Human Eye PrimaCell3: Normal Corneal Fibroblasts

2-96059 1 Kit Ask for price

Human Heart PrimaCell3: Normal Heart Fibroblasts

2-96068 1 Kit Ask for price

Human Lung PrimaCell1: Normal Lung Fibroblasts

2-96081 1 Kit Ask for price

Human Lymph PrimaCell3: Normal Lymphatic Fibroblasts

2-96089 1 Kit Ask for price

Human Mouth PrimaCell: Normal Periodontal Fibroblasts

2-96090 1 Kit Ask for price

Human Skin PrimaCell: Normal Skin Fibroblasts

2-96103 1 Kit Ask for price

Mouse Anti Human Fibroblasts/Epithelial Cells Monoclonal Antibody,RPE

DMABT-49595MH 25 TEST
EUR 429

Mouse Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts

2-82031 1 Kit Ask for price

Mouse Lung PrimaCell4: Normal Pulmonary Artery Fibroblasts

2-82067 1 Kit Ask for price

Rat Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts

2-82532 1 Kit Ask for price

Rat Lung PrimaCell3: Normal Pulmonary Artery Fibroblasts

2-82566 1 Kit Ask for price

Human Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts

2-96051 1 Kit Ask for price

Human Lung PrimaCell3: Normal Pulmonary Artery Fibroblasts

2-96083 1 Kit Ask for price

Human Cancer PrimaCell7: Esophageal Fibroblasts Growth Medium

9-46030 5 x 100 ml Ask for price

Immortalized Mouse Embryonic Cystic Fibrosis Fibroblasts-Myc

T0253 1x106 cells / 1.0 ml Ask for price

Immortalized Mouse Embryonic Cystic Fibrosis Fibroblasts-SV40

T0257 1x106 cells / 1.0 ml Ask for price

Immortalized Mouse Embryonic Cystic Fibrosis Fibroblasts-Ras

T0258 1x106 cells / 1.0 ml Ask for price

Immortalized Bcl-x Mouse Embryonic Fibroblasts - SV40T

T0749 1x106 cells / 1.0 ml Ask for price

Kidney Dissociation System 5 (Fibroblasts), Mouse and Rat

4-29295 ea Ask for price

Rat Bladder PrimaCell2: Normal Bladder Fibroblasts Growth Medium

9-25007 5 x 100 ml Ask for price

Rat Brain PrimaCell1: Normal Brain Fibroblasts Growth Medium

9-25011 5 x 100 ml Ask for price

Rat Cervix PrimaCell2: Normal Cervical Fibroblasts Growth Medium

9-25025 5 x 100 ml Ask for price

Rat Eye PrimaCell3: Normal Corneal Fibroblasts Growth Medium

9-25040 5 x 100 ml Ask for price

Rat Heart PrimaCell3: Normal Heart Fibroblasts Growth Medium

9-25048 5 x 100 ml Ask for price

Rat Lung PrimaCell1: Normal Lung Fibroblasts Growth Medium

9-25064 5 x 100 ml Ask for price

Rat Lymph PrimaCell3: Normal Lymphatic Fibroblasts Growth Medium

9-25072 5 x 100 ml Ask for price

Mouse Bladder PrimaCell2: Normal Bladder Fibroblasts Growth Medium

9-32007 5 x 100 ml Ask for price

Mouse Brain PrimaCell1: Normal Brain Fibroblasts Growth Medium

9-32010 5 x 100 ml Ask for price

Mouse Cervix PrimaCell2: Normal Cervical Fibroblasts Growth Medium

9-32024 5 x 100 ml Ask for price

Mouse Eye PrimaCell3: Normal Corneal Fibroblasts Growth Medium

9-32039 5 x 100 ml Ask for price

Mouse Heart PrimaCell3: Normal Heart Fibroblasts Growth Medium

9-32047 5 x 100 ml Ask for price

Mouse Lung PrimaCell2: Normal Lung Fibroblasts Growth Medium

9-32065 5 x 100 ml Ask for price

Mouse Lymph PrimaCell3: Normal Lymphatic Fibroblasts Growth Medium

9-32073 5 x 100 ml Ask for price

Human Bladder PrimaCell2: Normal Bladder Fibroblasts Growth Medium

9-46008 5 x 100 ml Ask for price

Human Brain PrimaCell1: Normal Brain Fibroblasts Growth Medium

9-46013 5 x 100 ml Ask for price

Human Cervix PrimaCell2: Normal Cervical Fibroblasts Growth Medium

9-46045 5 x 100 ml Ask for price

Human Eye PrimaCell3: Normal Corneal Fibroblasts Growth Medium

9-46059 5 x 100 ml Ask for price

Human Heart PrimaCell3: Normal Heart Fibroblasts Growth Medium

9-46068 5 x 100 ml Ask for price

Human Lung PrimaCell1: Normal Lung Fibroblasts Growth Medium

9-46081 5 x 100 ml Ask for price

Human Lymph PrimaCell3: Normal Lymphatic Fibroblasts Growth Medium

9-46089 5 x 100 ml Ask for price

Human Mouth PrimaCell: Normal Periodontal Fibroblasts Growth Medium

9-46090 5 x 100 ml Ask for price

Human Skin PrimaCell: Normal Skin Fibroblasts Growth Medium

9-46103 5 x 100 ml Ask for price

Human Cancer Tissue Preparation Buffer 7: Esophageal Fibroblasts

9-80030 1 x 100 ml Ask for price

Human Mouth Tissue Preparation Buffer: Normal Periodontal Fibroblasts

9-80090 1 x 100 ml Ask for price

Mouse Ariway PrimaCell3: Normal Bronchial and and Tracheal Fibroblasts

2-82003 1 Kit Ask for price

Rat Ariway PrimaCell3: Normal Bronchial and and Tracheal Fibroblasts

2-82503 1 Kit Ask for price

Human Airway PrimaCell4: Normal Bronchial and and Tracheal Fibroblasts

2-96004 1 Kit Ask for price

Heart Dissociation System 11 (Cardiomycytes,Fibroblasts), Mouse and Rat

4-20281 ea Ask for price

Rat Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts Growth Medium

9-25032 5 x 100 ml Ask for price

Rat Lung PrimaCell3: Normal Pulmonary Artery Fibroblasts Growth Medium

9-25066 5 x 100 ml Ask for price

Mouse Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts Growth Medium

9-32031 5 x 100 ml Ask for price

Mouse Lung PrimaCell4: Normal Pulmonary Artery Fibroblasts Growth Medium

9-32067 5 x 100 ml Ask for price

Human Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts Growth Medium

9-46051 5 x 100 ml Ask for price

Human Lung PrimaCell3: Normal Pulmonary Artery Fibroblasts Growth Medium

9-46083 5 x 100 ml Ask for price

Human Bladder Tissue Preparation Buffer 2: Normal Bladder Fibroblasts

9-80008 1 x 100 ml Ask for price

Human Brain Tissue Preparation Buffer 1: Normal Brain Fibroblasts

9-80013 1 x 100 ml Ask for price

Human Cervix Tissue Preparation Buffer 2: Normal Cervical Fibroblasts

9-80045 1 x 100 ml Ask for price

Human Eye Tissue Preparation Buffer 3: Normal Corneal Fibroblasts

9-80059 1 x 100 ml Ask for price

Human Heart Tissue Preparation Buffer 3: Normal Heart Fibroblasts

9-80068 1 x 100 ml Ask for price

Human Lung Tissue Preparation Buffer 1: Normal Lung Fibroblasts

9-80081 1 x 100 ml Ask for price

Human Lymph Tissue Preparation Buffer 3: Normal Lymphatic Fibroblasts

9-80089 1 x 100 ml Ask for price

Human Skin Tissue Preparation Buffer 3: Normal Skin Fibroblasts

9-80103 1 x 100 ml Ask for price

Mouse Bladder Tissue Preparation Buffer 2: Normal Bladder Fibroblasts

9-80121 1 x 100 ml Ask for price

Mouse Brain Tissue Preparation Buffer 1: Normal Brain Fibroblasts

9-80124 1 x 100 ml Ask for price

Mouse Cervix Tissue Preparation Buffer 2: Normal Cervical Fibroblasts

9-80138 1 x 100 ml Ask for price

Mouse Eye Tissue Preparation Buffer 3: Normal Corneal Fibroblasts

9-80153 1 x 100 ml Ask for price

Mouse Heart Tissue Preparation Buffer 3: Normal Heart Fibroblasts

9-80161 1 x 100 ml Ask for price

Mouse Lung Tissue Preparation Buffer 2: Normal Lung Fibroblasts

9-80179 1 x 100 ml Ask for price

Mouse Lymph Tissue Preparation Buffer 3: Normal Lymphatic Fibroblasts

9-80187 1 x 100 ml Ask for price

Rat Bladder Tissue Preparation Buffer 2: Normal Bladder Fibroblasts

9-80214 1 x 100 ml Ask for price

Rat Brain Tissue Preparation Buffer 1: Normal Brain Fibroblasts

9-80218 1 x 100 ml Ask for price

Rat Cervix Tissue Preparation Buffer 2: Normal Cervical Fibroblasts

9-80232 1 x 100 ml Ask for price

Rat Eye Tissue Preparation Buffer 3: Normal Corneal Fibroblasts

9-80247 1 x 100 ml Ask for price

Rat Heart Tissue Preparation Buffer 3: Normal Heart Fibroblasts

9-80255 1 x 100 ml Ask for price

Rat Lung Tissue Preparation Buffer 1: Normal Lung Fibroblasts

9-80271 1 x 100 ml Ask for price

Rat Lymph Tissue Preparation Buffer 3: Normal Lymphatic Fibroblasts

9-80279 1 x 100 ml Ask for price

Lung Dissociation System 6 (Fibroblasts & Type II), Mouse and Rat

4-20316 ea Ask for price

Human Embryo Tissue Preparation Buffer 2: Normal Fetal Dermal Fibroblasts

9-80051 1 x 100 ml Ask for price

Human Lung Tissue Preparation Buffer 3: Normal Pulmonary Artery Fibroblasts

9-80083 1 x 100 ml Ask for price

Mouse Embryo Tissue Preparation Buffer 2: Normal Fetal Dermal Fibroblasts

9-80145 1 x 100 ml Ask for price

Mouse Lung Tissue Preparation Buffer 4: Normal Pulmonary Artery Fibroblasts

9-80181 1 x 100 ml Ask for price

Rat Embryo Tissue Preparation Buffer 2: Normal Fetal Dermal Fibroblasts

9-80239 1 x 100 ml Ask for price

Rat Lung Tissue Preparation Buffer 3: Normal Pulmonary Artery Fibroblasts

9-80273 1 x 100 ml Ask for price

Cartilage Dissociation System 1 (Mesenchymal, Fibroblasts, Epithelial-like), Mouse and Rat

4-20231 ea Ask for price

Rat Ariway PrimaCell3: Normal Bronchial and and Tracheal Fibroblasts Growth Medium

9-25003 5 x 100 ml Ask for price

Mouse Ariway PrimaCell3: Normal Bronchial and and Tracheal Fibroblasts Growth Medium

9-32003 5 x 100 ml Ask for price

Human Airway PrimaCell4: Normal Bronchial and and Tracheal Fibroblasts Growth Medium

9-46004 5 x 100 ml Ask for price

Human Airway Tissue Preparation Buffer 4: Normal Bronchial and and Tracheal Fibroblasts

9-80004 1 x 100 ml Ask for price

Mouse Ariway Tissue Preparation Buffer 3: Normal Bronchial and and Tracheal Fibroblasts

9-80117 1 x 100 ml Ask for price

Rat Ariway Tissue Preparation Buffer 3: Normal Bronchial and and Tracheal Fibroblasts

9-80210 1 x 100 ml Ask for price

Human Cancer PrimaCell7: Esophageal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47030 1 Set Ask for price

Rat Bladder PrimaCell2: Normal Bladder Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-26007 1 Set Ask for price

Rat Brain PrimaCell1: Normal Brain Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-26011 1 Set Ask for price

Rat Cervix PrimaCell2: Normal Cervical Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-26025 1 Set Ask for price

Rat Eye PrimaCell3: Normal Corneal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-26040 1 Set Ask for price

Rat Heart PrimaCell3: Normal Heart Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-26048 1 Set Ask for price

Rat Lung PrimaCell1: Normal Lung Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-26064 1 Set Ask for price

Rat Lymph PrimaCell3: Normal Lymphatic Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-26072 1 Set Ask for price

Mouse Bladder PrimaCell2: Normal Bladder Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-33007 1 Set Ask for price

Mouse Brain PrimaCell1: Normal Brain Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-33010 1 Set Ask for price

Mouse Cervix PrimaCell2: Normal Cervical Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-33024 1 Set Ask for price

Mouse Eye PrimaCell3: Normal Corneal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-33039 1 Set Ask for price

Mouse Heart PrimaCell3: Normal Heart Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-33047 1 Set Ask for price

Mouse Lung PrimaCell2: Normal Lung Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-33065 1 Set Ask for price

Mouse Lymph PrimaCell3: Normal Lymphatic Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-33073 1 Set Ask for price

Human Bladder PrimaCell2: Normal Bladder Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47008 1 Set Ask for price

Human Brain PrimaCell1: Normal Brain Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47013 1 Set Ask for price

Human Cervix PrimaCell2: Normal Cervical Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47045 1 Set Ask for price

Human Eye PrimaCell3: Normal Corneal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47059 1 Set Ask for price

Human Heart PrimaCell3: Normal Heart Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47068 1 Set Ask for price

Human Lung PrimaCell1: Normal Lung Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47081 1 Set Ask for price

Human Lymph PrimaCell3: Normal Lymphatic Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47089 1 Set Ask for price

Human Mouth PrimaCell: Normal Periodontal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47090 1 Set Ask for price

Human Skin PrimaCell: Normal Skin Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47103 1 Set Ask for price

Rat Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-26032 1 Set Ask for price

Rat Lung PrimaCell3: Normal Pulmonary Artery Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-26066 1 Set Ask for price

Mouse Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-33031 1 Set Ask for price

Mouse Lung PrimaCell4: Normal Pulmonary Artery Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-33067 1 Set Ask for price

Human Embryo PrimaCell2: Normal Fetal Dermal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47051 1 Set Ask for price

Human Lung PrimaCell3: Normal Pulmonary Artery Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47083 1 Set Ask for price

Rat Ariway PrimaCell3: Normal Bronchial and and Tracheal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-26003 1 Set Ask for price

Mouse Ariway PrimaCell3: Normal Bronchial and and Tracheal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-33003 1 Set Ask for price

Human Airway PrimaCell4: Normal Bronchial and and Tracheal Fibroblasts Growth Supplements with Serum (for 500 ml medium)

9-47004 1 Set Ask for price

H2B Antibody Antibody

AF4659 200ul
EUR 376
Description: H2B Antibody Antibody detects endogenous levels of H2B.

CD11b Antibody Antibody

ABD2911 100 ug
EUR 438

anti- Antibody^Polyclonal antibody control antibody

LSMab09882 100 ug
EUR 438

Ly1 Antibody Reactive (LYAR) Antibody

20-abx008109
  • EUR 300.00
  • EUR 439.00
  • EUR 189.00
  • 100 ul
  • 200 ul
  • 30 ul
  • Shipped within 5-10 working days.

Anti-Glycolipid Antibody (AGA) Antibody

20-abx004855
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx123734
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.

Anti-Glycolipid Antibody (AGA) Antibody

abx036399-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx014333
  • EUR 314.00
  • EUR 98.00
  • EUR 398.00
  • EUR 495.00
  • 100 ug
  • 10 ug
  • 200 ug
  • 300 µg
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

abx033330-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

abx033330-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319900
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319901
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319905
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycoprotein Antibody (GP) Antibody

20-abx319913
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

abx234901-100ug 100 ug
EUR 551
  • Shipped within 5-12 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx324434
  • EUR 314.00
  • EUR 244.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Ly1 Antibody Reactive (LYAR) Antibody

20-abx311665
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Anti-Glycolipid Antibody (AGA) Antibody

abx230204-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Anti-Anti-SEPT6 antibody antibody

STJ11100949 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis. One version of pediatric acute myeloid leukemia is the result of a reciprocal translocation between chromosomes 11 and X, with the breakpoint associated with the genes encoding the mixed-lineage leukemia and septin 2 proteins. This gene encodes four transcript variants encoding three distinct isoforms. An additional transcript variant has been identified, but its biological validity has not been determined.

Anti-Anti-SEPT9 Antibody antibody

STJ111369 100 µl
EUR 277
Description: This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.

Anti-Anti-SEPT11 Antibody antibody

STJ111530 100 µl
EUR 277

Anti-Anti-SEPT4 Antibody antibody

STJ112276 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is highly expressed in brain and heart. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. One of the isoforms (known as ARTS) is distinct; it is localized to the mitochondria, and has a role in apoptosis and cancer.

Anti-Anti-SEPT2 Antibody antibody

STJ25475 100 µl
EUR 277

Anti-Anti-SEPT5 Antibody antibody

STJ25477 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Anti-Anti-SEPT8 Antibody antibody

STJ25479 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-SEPT2 Antibody antibody

STJ28365 100 µl
EUR 277

Anti-Anti-SEPT7 Antibody antibody

STJ28963 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

Anti-Anti-MARCH9 Antibody antibody

STJ112609 100 µl
EUR 277

Anti-Anti-SEPT11 Antibody antibody

STJ113941 100 µl
EUR 277

Anti-Anti-SEPT11 Antibody antibody

STJ114081 100 µl
EUR 277

Anti-Anti-SEPT5 Antibody antibody

STJ114819 100 µl
EUR 277
Description: This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced.

Anti-Anti-MARCH8 Antibody antibody

STJ114828 100 µl
EUR 277

Anti-Anti-SEPT7 Antibody antibody

STJ116214 100 µl
EUR 277
Description: This gene encodes a protein that is highly similar to the CDC10 protein of Saccharomyces cerevisiae. The protein also shares similarity with Diff 6 of Drosophila and with H5 of mouse. Each of these similar proteins, including the yeast CDC10, contains a GTP-binding motif. The yeast CDC10 protein is a structural component of the 10 nm filament which lies inside the cytoplasmic membrane and is essential for cytokinesis. This human protein functions in gliomagenesis and in the suppression of glioma cell growth, and it is required for the association of centromere-associated protein E with the kinetochore. Alternative splicing results in multiple transcript variants. Several related pseudogenes have been identified on chromosomes 5, 7, 9, 10, 11, 14, 17 and 19.

Anti-Anti-SEPT8 Antibody antibody

STJ117206 100 µl
EUR 277
Description: This gene is a member of the septin family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse, and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-SEPT12 Antibody antibody

STJ117759 100 µl
EUR 277
Description: This gene encodes a guanine-nucleotide binding protein and member of the septin family of cytoskeletal GTPases. Septins play important roles in cytokinesis, exocytosis, embryonic development, and membrane dynamics. Multiple transcript variants encoding different isoforms have been found for this gene.

Anti-Anti-MARCH6 Antibody antibody

STJ118549 100 µl
EUR 277

Anti-Anti-MARCH6 Antibody antibody

STJ118550 100 µl
EUR 277

Anti-Anti-MARCH7 Antibody antibody

STJ118752 100 µl
EUR 277

Anti-Anti-SEPT3 Antibody antibody

STJ118990 100 µl
EUR 277

Anti-Anti-SEPT1 antibody antibody

STJ119580 100 µl
EUR 277
Description: This gene is a member of the septin family of GTPases. Members of this family are required for cytokinesis and the maintenance of cellular morphology. This gene encodes a protein that can form homo- and heterooligomeric filaments, and may contribute to the formation of neurofibrillary tangles in Alzheimer's disease. Alternatively spliced transcript variants have been found but the full-length nature of these variants has not been determined. [provided by RefSeq, Dec 2012]

Cytokeratin 7 antibody-Cytoskeleton Marker Antibody

48169-100ul 100ul
EUR 333

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